ABSTRACT
Asymptomatic subjects account for 25 to 45% of SARS-CoV-2 infections, and in particular, subjects on mild immunosuppressive therapy may have symptoms masked and could spread virus for an extended period of time. To determine the cumulative incidence of symptomatic and asymptomatic SARS-CoV-2 infections and associated risk factors, we conducted a prospective clinical and serological survey in a cohort of 278 liver transplant recipients (LTRs) from Central Italy. Three different serology tests were performed every 4 months in 259 LTRs between April 2020 and April 2021: one based on raw extract of whole SARS-CoV-2 virus and two on specific viral antigens (nucleoprotein and receptor binding domain) to detect specific IgG, IgM and IgA. Hundred fifteen LTRs who reported symptoms or close contact with a SARS-CoV-2-positive subject, or had a positive serological result underwent molecular testing by standard screening procedures (RT-PCR on naso-pharyngeal swab). Thirty-one past or active SARS-CoV-2 infections were identified: 14 had positive molecular test (64% symptomatic), and 17 had positive serology only (18% symptomatic). SARS-CoV-2 infection was not statistically related to gender, age, obesity, diabetes, renal impairment, type of anti-rejection therapy or time from transplant. Asymptomatic SARS-CoV-2 cases (61.3%) were more frequent in males and in those with glomerular filtrate rate >50 ml/min. Overall, the addition of repeated serology to standard diagnostic molecular protocols increased detection of SARS-CoV-2 infection from 5.1% to 10.9%. Anti-SARS-CoV-2 seroprevalence among our LTRs (11.2%) is comparable to the general population of Central Italy, considered a medium-impact area. Only one asymptomatic subject (6%) was found to carry SARS-CoV-2 in respiratory tract at the time of serological diagnosis.Copyright © 2021 The Authors
ABSTRACT
In its one hundred years of existence, the Communist Party of China has experimented with how to connect its narratives of legitimacy to people's affects. In this essay, I trace the conceptualization of gratitude, from its repudiation in the Mao era as a vestige of feudalism and imperialism to its return in the reform era as a re-verticalization of Party sovereignty. The paper addresses four examples of gratitude work: Politburo Standing Committee member Wang Yang's short-lived critique of gratitude in the name of a different conception of popular sovereignty;the celebration of the tenth anniversary of the Sichuan earthquake as a day of gratitude;the detention of Uyghurs in Xinjiang who are taught to be grateful to the Communist Party in a campaign of religious de-radicalization;and the refusal of gratitude in quarantined Wuhan during the COVID-19 pandemic. In these cases, the Communist Party's sovereignty stands at the threshold between bio-and necro-politics, promising life and salvation in the midst of death and destruction. Copyright © The Author(s), 2021. Published by Cambridge University Press.